New Invention: Cellular Impedance Biosensor for drug testing applications


One inventor from Malaysia have presented at the IENA Invention Fair 2013 his invention:


Cellular Impedance Biosensor for drug testing applications..”




Electrical cell-substrate impedance sensing (ECIS) is a valuable tool for real monitoring of cell behavior such as attachment, mobility and growth. In the ECIS sensor, cells attach, spread and

proliferate on the electrode in the presence of adhesion – promoting protein that mimics the extracellular matrix (ECM). To promote cell attachment, collagen I. Bovine had been used as the coating substrate. In this study, four biosensor designs with varying electrode distance were tested with Lung Carcinoma cell lines , A 549. The impedance measurements were measured at 8 hour intervals for 120 hours using the Impedance Analyzer (Agilent 4294 A). It was observed that the electrodes with the closest spacing showed the best impedance reading with 100 Hz as the optimum frequency to measure the impedance changes. To test the drug efficacy on the cancer cell lines , the A549 cell lines were treated with Taxol. In conclusion , the fabricated biosensor has been proven to be effective and sensitive as an alternative screening method for drug testing.



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